Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
5ht1a_human | 420 | C-term | C => R | missense | 8.237e-06 | 1 | 121400 | 0 | 0.51 | 0.671 | ||
5ht1a_human | 413 | 8.56x56 | H8 | K => N | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 0.999 | |
5ht1a_human | 410 | 8.53x53 | H8 | A => G | missense | 8.236e-06 | 1 | 121412 | 0 | 0.01 | 0.998 | |
5ht1a_human | 397 | 7.50x50 | TM7 | P => L | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
5ht1a_human | 390 | 7.43x42 | TM7 | Y => H | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 1.0 | LB (Van der Waals, hydrophobic) |
5ht1a_human | 389 | 7.42x41 | TM7 | G => D | missense | 8.236e-06 | 1 | 121412 | 0 | 0.03 | 1.0 | |
5ht1a_human | 387 | 7.40x39 | TM7 | W => R | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 1.0 | |
5ht1a_human | 382 | 7.35x34 | TM7 | G => S | missense | 8.237e-06 | 1 | 121410 | 0 | 0.48 | 0.524 | |
5ht1a_human | 379 | 7.32x31 | TM7 | T => N | missense | 8.236e-06 | 1 | 121412 | 0 | 0.41 | 0.004 | |
5ht1a_human | 370 | 6.60x60 | TM6 | F => C | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 1.0 | |
5ht1a_human | 369 | 6.59x59 | TM6 | P => L | missense | 8.236e-06 | 1 | 121412 | 0 | 0.0 | 0.943 | |
5ht1a_human | 367 | 6.57x57 | TM6 | V => I | missense | 1.647e-05 | 2 | 121412 | 0 | 0.2 | 0.099 | |
5ht1a_human | 364 | 6.54x54 | TM6 | V => M | missense | 8.237e-06 | 1 | 121408 | 0 | 0.24 | 0.984 | |
5ht1a_human | 363 | 6.53x53 | TM6 | I => L | missense | 8.237e-06 | 1 | 121406 | 0 | 0.08 | 0.454 | |
5ht1a_human | 361 | 6.51x51 | TM6 | F => L | missense | 8.237e-06 | 1 | 121406 | 0 | 0.0 | 0.559 | LB (hydrophobic, Van der Waals) |
5ht1a_human | 356 | 6.46x46 | TM6 | L => I | missense | 8.238e-06 | 1 | 121386 | 0 | 0.49 | 0.645 | |
5ht1a_human | 346 | 6.36x36 | TM6 | T => M | missense | 8.24e-06 | 1 | 121352 | 0 | 0.0 | 0.996 | GP (contact) |
5ht1a_human | 341 | 6.31x31 | TM6 | R => K | missense | 8.242e-06 | 1 | 121328 | 0 | 0.1 | 0.12 | |
5ht1a_human | 341 | 6.31x31 | TM6 | R => M | missense | 8.242e-06 | 1 | 121328 | 0 | 0.0 | 0.981 | |
5ht1a_human | 339 | 6.29x29 | TM6 | R => P | missense | 2.473e-05 | 3 | 121324 | 0 | 0.0 | 0.997 | GP (contact) |
5ht1a_human | 335 | 6.25x25 | TM6 | M => I | missense | 5.771e-05 | 7 | 121294 | 0 | 0.59 | 0.01 | GP (contact) |
5ht1a_human | 334 | 6.24x24 | TM6 | K => Q | missense | 0.0002639 | 32 | 121278 | 0 | 0.02 | 0.955 | PTM (Ubiquitylation) |
5ht1a_human | 333 | 6.23x23 | TM6 | R => L | missense | 8.248e-06 | 1 | 121244 | 0 | 0.0 | 0.982 | |
5ht1a_human | 332 | 6.22x22 | TM6 | K => T | missense | 8.248e-06 | 1 | 121242 | 0 | 0.04 | 0.93 | |
5ht1a_human | 331 | 6.21x21 | TM6 | A => G | missense | 8.25e-06 | 1 | 121216 | 0 | 0.03 | 0.182 | |
5ht1a_human | 330 | 6.20x20 | TM6 | E => D | missense | 8.251e-06 | 1 | 121194 | 0 | 0.21 | 0.097 | |
5ht1a_human | 325 | 6.15x15 | TM6 | N => T | missense | 8.259e-06 | 1 | 121086 | 0 | 0.26 | 0.61 | |
5ht1a_human | 324 | 6.14x14 | TM6 | K => E | missense | 8.262e-06 | 1 | 121036 | 0 | 0.24 | 0.314 | PTM (Acetylation) |
5ht1a_human | 317 | ICL3 | A => V | missense | 8.283e-06 | 1 | 120732 | 0 | 0.59 | 0.004 | ||
5ht1a_human | 317 | ICL3 | A => P | missense | 8.286e-06 | 1 | 120692 | 0 | 0.41 | 0.006 | ||
5ht1a_human | 315 | ICL3 | P => R | missense | 8.288e-06 | 1 | 120658 | 0 | 0.05 | 0.723 | ||
5ht1a_human | 315 | ICL3 | P => L | missense | 1.658e-05 | 2 | 120658 | 0 | 0.03 | 0.305 | ||
5ht1a_human | 314 | ICL3 | T => N | missense | 1.658e-05 | 2 | 120640 | 0 | 0.54 | 0.003 | ||
5ht1a_human | 311 | ICL3 | A => T | missense | 1.66e-05 | 2 | 120502 | 0 | 0.43 | 0.077 | ||
5ht1a_human | 310 | ICL3 | E => K | missense | 1.66e-05 | 2 | 120494 | 0 | 0.82 | 0.052 | ||
5ht1a_human | 309 | ICL3 | S => R | missense | 2.491e-05 | 3 | 120444 | 0 | 0.54 | 0.023 | ||
5ht1a_human | 306 | ICL3 | P => L | missense | 1.661e-05 | 2 | 120384 | 0 | 0.14 | 0.939 | ||
5ht1a_human | 306 | ICL3 | P => S | missense | 8.306e-06 | 1 | 120388 | 0 | 0.41 | 0.483 | ||
5ht1a_human | 304 | ICL3 | H => Q | missense | 8.307e-06 | 1 | 120382 | 0 | 0.45 | 0.906 | ||
5ht1a_human | 301 | ICL3 | S => F | missense | 4.154e-05 | 5 | 120362 | 0 | 0.0 | 0.25 | ||
5ht1a_human | 300 | ICL3 | N => S | missense | 8.31e-05 | 10 | 120344 | 0 | 0.6 | 0.002 | ||
5ht1a_human | 300 | ICL3 | N => I | missense | 8.31e-06 | 1 | 120344 | 0 | 0.05 | 0.005 | ||
5ht1a_human | 298 | ICL3 | V => L | missense | 8.312e-06 | 1 | 120312 | 0 | 0.65 | 0.001 | ||
5ht1a_human | 297 | ICL3 | R => G | missense | 8.312e-06 | 1 | 120304 | 0 | 0.45 | 0.134 | ||
5ht1a_human | 295 | ICL3 | V => L | missense | 8.31e-06 | 1 | 120342 | 0 | 0.48 | 0.07 | ||
5ht1a_human | 294 | ICL3 | E => Q | missense | 1.662e-05 | 2 | 120320 | 0 | 0.13 | 0.99 | ||
5ht1a_human | 285 | ICL3 | D => E | missense | 1.661e-05 | 2 | 120414 | 0 | 1.0 | 0.005 | ||
5ht1a_human | 285 | ICL3 | D => E | missense | 8.305e-06 | 1 | 120414 | 0 | 1.0 | 0.005 | ||
5ht1a_human | 275 | ICL3 | L => V | missense | 8.31e-06 | 1 | 120336 | 0 | 0.38 | 0.002 | ||
5ht1a_human | 274 | ICL3 | A => G | missense | 6.649e-05 | 8 | 120322 | 0 | 0.4 | 0.002 | ||
5ht1a_human | 273 | ICL3 | G => D | missense | 0.001571 | 189 | 120328 | 3 | 0.56 | 0.243 | ||
5ht1a_human | 273 | ICL3 | G => V | missense | 8.311e-06 | 1 | 120328 | 0 | 0.3 | 0.016 | ||
5ht1a_human | 273 | ICL3 | G => S | missense | 1.662e-05 | 2 | 120336 | 0 | 0.84 | 0.016 | ||
5ht1a_human | 272 | ICL3 | G => R | missense | 8.312e-06 | 1 | 120304 | 0 | 0.53 | 0.034 | ||
5ht1a_human | 269 | ICL3 | S => R | missense | 8.316e-06 | 1 | 120256 | 0 | 0.47 | 0.005 | ||
5ht1a_human | 269 | ICL3 | S => T | missense | 8.316e-06 | 1 | 120252 | 0 | 0.55 | 0.003 | ||
5ht1a_human | 267 | ICL3 | V => L | missense | 8.319e-06 | 1 | 120206 | 0 | 0.34 | 0.006 | ||
5ht1a_human | 262 | ICL3 | N => S | missense | 8.323e-06 | 1 | 120146 | 0 | 1.0 | 0.002 | ||
5ht1a_human | 251 | ICL3 | K => N | missense | 8.351e-06 | 1 | 119744 | 0 | 0.33 | 0.261 | ||
5ht1a_human | 250 | ICL3 | P => S | missense | 5.012e-05 | 6 | 119712 | 0 | 0.76 | 0.003 | ||
5ht1a_human | 247 | ICL3 | A => V | missense | 8.356e-06 | 1 | 119678 | 0 | 0.26 | 0.028 | ||
5ht1a_human | 247 | ICL3 | A => T | missense | 1.671e-05 | 2 | 119706 | 0 | 0.28 | 0.029 | ||
5ht1a_human | 245 | ICL3 | S => F | missense | 8.356e-06 | 1 | 119670 | 0 | 0.1 | 0.649 | ||
5ht1a_human | 244 | ICL3 | A => T | missense | 3.343e-05 | 4 | 119664 | 0 | 0.68 | 0.003 | ||
5ht1a_human | 243 | ICL3 | G => A | missense | 8.374e-06 | 1 | 119416 | 0 | 0.72 | 0.003 | ||
5ht1a_human | 242 | ICL3 | H => Q | missense | 8.394e-06 | 1 | 119130 | 0 | 0.63 | 0.011 | ||
5ht1a_human | 237 | ICL3 | G => R | missense | 6.709e-05 | 8 | 119234 | 0 | 0.48 | 0.003 | ||
5ht1a_human | 236 | ICL3 | T => I | missense | 8.368e-06 | 1 | 119498 | 0 | 0.14 | 0.0 | ||
5ht1a_human | 223 | 5.66x66 | TM5 | R => H | missense | 8.302e-06 | 1 | 120452 | 0 | 0.03 | 0.998 | GP (contact) |
5ht1a_human | 223 | 5.66x66 | TM5 | R => C | missense | 8.299e-06 | 1 | 120498 | 0 | 0.0 | 0.998 | GP (contact) |
5ht1a_human | 222 | 5.65x65 | TM5 | A => V | missense | 8.297e-06 | 1 | 120528 | 0 | 0.0 | 0.997 | GP (contact) |
5ht1a_human | 220 | 5.63x63 | TM5 | R => L | missense | 0.003612 | 436 | 120694 | 1 | 0.15 | 0.647 | |
5ht1a_human | 219 | 5.62x62 | TM5 | F => L | missense | 8.279e-06 | 1 | 120788 | 0 | 0.02 | 0.593 | |
5ht1a_human | 218 | 5.61x61 | TM5 | I => K | missense | 8.271e-06 | 1 | 120904 | 0 | 0.0 | 0.993 | GP (contact) |
5ht1a_human | 217 | 5.60x60 | TM5 | R => L | missense | 8.27e-06 | 1 | 120916 | 0 | 0.0 | 0.932 | |
5ht1a_human | 208 | 5.51x51 | TM5 | L => P | missense | 1.653e-05 | 2 | 120968 | 0 | 0.0 | 1.0 | |
5ht1a_human | 205 | 5.48x48 | TM5 | Y => C | missense | 8.268e-06 | 1 | 120944 | 0 | 0.0 | 1.0 | PTM (Phosphorylation) |
5ht1a_human | 199 | 5.42x43 | TM5 | S => P | missense | 8.276e-06 | 1 | 120826 | 0 | 0.01 | 1.0 | PTM (Phosphorylation) LB (Van der Waals) |
5ht1a_human | 197 | 5.40x41 | TM5 | I => V | missense | 8.278e-06 | 1 | 120804 | 0 | 0.31 | 0.773 | |
5ht1a_human | 193 | 5.36x37 | TM5 | H => R | missense | 2.485e-05 | 3 | 120742 | 0 | 0.37 | 0.189 | |
5ht1a_human | 186 | ECL2 | A => E | missense | 8.292e-06 | 1 | 120604 | 0 | 0.46 | 0.247 | ||
5ht1a_human | 186 | ECL2 | A => T | missense | 8.292e-06 | 1 | 120598 | 0 | 0.47 | 0.377 | ||
5ht1a_human | 184 | ECL2 | P => T | missense | 8.295e-06 | 1 | 120558 | 0 | 0.2 | 0.895 | ||
5ht1a_human | 182 | ECL2 | S => L | missense | 0.0005476 | 66 | 120532 | 0 | 0.25 | 0.008 | ||
5ht1a_human | 171 | 4.60x60 | TM4 | P => L | missense | 8.3e-06 | 1 | 120478 | 0 | 0.0 | 1.0 | |
5ht1a_human | 168 | 4.57x57 | TM4 | S => F | missense | 1.66e-05 | 2 | 120460 | 0 | 0.0 | 1.0 | |
5ht1a_human | 167 | 4.56x56 | TM4 | I => M | missense | 8.302e-06 | 1 | 120458 | 0 | 0.0 | 1.0 | |
5ht1a_human | 167 | 4.56x56 | TM4 | I => L | missense | 4.152e-05 | 5 | 120420 | 0 | 0.01 | 0.999 | |
5ht1a_human | 167 | 4.56x56 | TM4 | I => F | missense | 8.304e-06 | 1 | 120420 | 0 | 0.0 | 1.0 | |
5ht1a_human | 155 | 4.44x44 | TM4 | A => G | missense | 0.0005568 | 67 | 120336 | 1 | 0.02 | 0.678 | |
5ht1a_human | 152 | 4.41x41 | TM4 | R => L | missense | 8.31e-06 | 1 | 120330 | 0 | 0.0 | 1.0 | |
5ht1a_human | 151 | 4.40x40 | TM4 | R => W | missense | 8.31e-06 | 1 | 120340 | 0 | 0.0 | 0.995 | |
5ht1a_human | 150 | 4.39x39 | TM4 | P => R | missense | 8.31e-06 | 1 | 120336 | 0 | 0.01 | 0.995 | |
5ht1a_human | 148 | 34.57x57 | ICL2 | R => S | missense | 8.31e-06 | 1 | 120342 | 0 | 0.02 | 1.0 | GP (contact) |
5ht1a_human | 145 | 34.54x54 | ICL2 | V => M | missense | 8.316e-06 | 1 | 120246 | 0 | 0.27 | 0.265 | GP (contact) |
5ht1a_human | 145 | 34.54x54 | ICL2 | V => L | missense | 8.316e-06 | 1 | 120246 | 0 | 0.1 | 0.129 | GP (contact) |
5ht1a_human | 144 | 34.53x53 | ICL2 | Y => C | missense | 8.316e-06 | 1 | 120250 | 0 | 0.0 | 1.0 | GP (contact) |
5ht1a_human | 142 | 34.51x51 | ICL2 | I => T | missense | 8.316e-06 | 1 | 120246 | 0 | 0.0 | 0.983 | GP (contact) |
5ht1a_human | 139 | 3.55x55 | TM3 | T => M | missense | 1.665e-05 | 2 | 120146 | 0 | 0.0 | 1.0 | GP (contact) |
5ht1a_human | 134 | 3.50x50 | TM3 | R => S | missense | 8.336e-06 | 1 | 119966 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
5ht1a_human | 129 | 3.45x45 | TM3 | A => S | missense | 8.369e-06 | 1 | 119490 | 0 | 0.03 | 0.993 | |
5ht1a_human | 124 | 3.40x40 | TM3 | I => N | missense | 8.39e-06 | 1 | 119192 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
5ht1a_human | 115 | 3.31x31 | TM3 | L => F | missense | 2.537e-05 | 3 | 118270 | 0 | 0.28 | 1.0 | |
5ht1a_human | 111 | 3.27x27 | TM3 | L => V | missense | 3.387e-05 | 4 | 118094 | 0 | 0.1 | 0.351 | |
5ht1a_human | 99 | 2.67x66 | TM2 | L => F | missense | 0.0001355 | 16 | 118064 | 1 | 0.45 | 1.0 | |
5ht1a_human | 94 | 2.62x61 | TM2 | A => P | missense | 8.472e-06 | 1 | 118036 | 0 | 0.01 | 1.0 | |
5ht1a_human | 69 | 2.37x37 | TM2 | N => T | missense | 8.352e-06 | 1 | 119728 | 0 | 0.37 | 0.147 | |
5ht1a_human | 65 | 12.48x48 | ICL1 | R => S | missense | 8.338e-06 | 1 | 119936 | 0 | 0.0 | 1.0 | |
5ht1a_human | 62 | 1.58x58 | TM1 | A => V | missense | 8.333e-06 | 1 | 120004 | 0 | 1.0 | 0.012 | |
5ht1a_human | 61 | 1.57x57 | TM1 | I => M | missense | 8.332e-06 | 1 | 120024 | 0 | 0.0 | 0.997 | |
5ht1a_human | 61 | 1.57x57 | TM1 | I => V | missense | 8.33e-06 | 1 | 120046 | 0 | 0.13 | 0.721 | |
5ht1a_human | 53 | 1.49x49 | TM1 | G => V | missense | 8.327e-06 | 1 | 120088 | 0 | 0.0 | 1.0 | |
5ht1a_human | 51 | 1.47x47 | TM1 | V => L | missense | 8.327e-06 | 1 | 120092 | 0 | 0.03 | 0.004 | |
5ht1a_human | 50 | 1.46x46 | TM1 | A => G | missense | 2.498e-05 | 3 | 120094 | 0 | 0.09 | 0.019 | |
5ht1a_human | 39 | 1.35x35 | TM1 | T => I | missense | 5.002e-05 | 6 | 119942 | 0 | 0.05 | 0.839 | |
5ht1a_human | 33 | 1.29x29 | TM1 | V => I | missense | 1.669e-05 | 2 | 119816 | 0 | 0.07 | 0.008 | |
5ht1a_human | 31 | N-term | V => M | missense | 8.348e-06 | 1 | 119796 | 0 | 0.02 | 0.022 | ||
5ht1a_human | 30 | N-term | D => E | missense | 8.348e-06 | 1 | 119794 | 0 | 1.0 | 0.004 | ||
5ht1a_human | 28 | N-term | I => V | missense | 0.008885 | 1064 | 119752 | 12 | 0.66 | 0.0 | ||
5ht1a_human | 25 | N-term | T => A | missense | 8.355e-06 | 1 | 119682 | 0 | 0.96 | 0.0 | ||
5ht1a_human | 23 | N-term | G => D | missense | 8.354e-06 | 1 | 119702 | 0 | nan | 0.001 | ||
5ht1a_human | 22 | N-term | G => S | missense | 0.0001921 | 23 | 119704 | 0 | 0.4 | 0.002 | ||
5ht1a_human | 18 | N-term | P => L | missense | 8.356e-06 | 1 | 119672 | 0 | nan | 0.001 | ||
5ht1a_human | 18 | N-term | P => S | missense | 1.671e-05 | 2 | 119674 | 0 | nan | 0.001 | ||
5ht1a_human | 17 | N-term | A => S | missense | 8.357e-06 | 1 | 119662 | 0 | nan | 0.001 | ||
5ht1a_human | 16 | N-term | P => L | missense | 0.001646 | 197 | 119648 | 2 | nan | 0.0 | ||
5ht1a_human | 12 | N-term | T => S | missense | 1.672e-05 | 2 | 119624 | 0 | nan | 0.556 | ||
5ht1a_human | 11 | N-term | N => S | missense | 8.361e-06 | 1 | 119610 | 0 | nan | 0.043 | ||
5ht1a_human | 11 | N-term | N => T | missense | 4.18e-05 | 5 | 119610 | 0 | nan | 0.342 | ||
5ht1a_human | 9 | N-term | G => S | missense | 3.345e-05 | 4 | 119564 | 0 | nan | 0.001 | ||
5ht1a_human | 3 | N-term | V => M | missense | 0.0007373 | 88 | 119352 | 0 | nan | 0.007 | ||
5ht1a_human | 2 | N-term | D => G | missense | 8.386e-06 | 1 | 119250 | 0 | nan | 0.282 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue